1. Adhere to drupal best practices from the start. Look forward to your site being around for a long while and set it up correctly. Even the basics, like taking advantage of using the sites/all folder to hold your non-core modules and themes can save you a lot of time down the road.

2. Make the website accessible to a wide range of people. It is easier to plan things like text-size controls, email-to-a-friend and print buttons when you’re in the design stages. Adding them in afterwards can look amateurish.

3. Give yourself time to input content and give it some TLC with proper formatting. Nothing is more boring than the same basic text layout on every page. With CMS’s half the point is having the same frame around your content so that navigation is consistent, etc. – but that doesn’t mean your text and image content has to be the same with every node. Float an image left, float it right, pull out an important quote and give it the bold+italic treatment. Don’t rush through this “final part” of the job – it’s very important.

4. Use some kind of design/development framework. Whatever works for you, but the point is to keep it consistent so that when it comes time to fix something or add a feature you can do it quickly. For most people just starting out with the same basic theme, like Zen, is enough. Later on though you might need to start keeping a folder of your regular modules, pre-configured modules, sample configurations of certain key theme components, and anything else you might need within arms reach. A note of caution though – make sure you check drupal.org for updates of the modules once in awhile.

5. FCKeditor – is the best editor there is, period. A lot of folks swear by tinyMCE but I think they’re just plain wrong. FCK has a built in file manager (that is a pain in the ass to configure but very worth it), a default CSS XML-based stylesheet associated with user-styles that is easy to override,  but most importantly it has a feature tied into the text editor that shows block elements boundaries in your html structure which is of huge benefit to 99% of all users.

http://www.fckeditor.net/